The 10 Biggest U.S. Companies Raking in Revenue in 2025

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The Fortune 500 list is out, and the usual giants are still flexing hard.

From retail titans to healthcare juggernauts, these companies aren’t just making money — they’re shaping entire sectors.

Based on 2024 revenue, here are the 10 U.S. companies pulling in the most cash — and the trends worth watching as the economy shifts under their weight.

Walmart

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Still the undisputed king of revenue, Walmart holds the top spot for the 13th year running. With over $640 billion in revenue, it’s the one-stop shop America can’t quit — and its investment in automation and logistics is only making it stronger.

Amazon

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Amazon sits comfortably at No. 2, with e-commerce and cloud computing still delivering monster numbers. AWS alone would be a Fortune 100 company. Amazon’s warehouse-to-door dominance continues to reshape how Americans shop.

UnitedHealth Group

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At No. 3, UnitedHealth proves healthcare is big business. With over $360 billion in revenue, its mix of insurance, data, and care delivery makes it a major player in the future of American medicine.

Apple

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Apple clocks in at No. 4 with massive hardware and services revenue. iPhones still print money, but Apple’s pivot to subscriptions and AI-enhanced features has Wall Street watching closely.

CVS Health

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Another healthcare heavyweight, CVS pulled in more than $350 billion. With its mix of pharmacies, clinics, and insurance, CVS is playing the long game on healthcare access and delivery.

Berkshire Hathaway

New York, United States of America – 2023 March 10: Berkshire Hathaway company on stock market. Berkshire Hathaway financial success and profit

Buffett’s empire stays in the top 10 at No. 6. From railroads to insurance to energy, Berkshire’s portfolio is old-school diversified — and still pulling in more than $300 billion.

Alphabet (Google)

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At No. 7, Alphabet keeps riding the digital wave. Search, YouTube, and cloud computing are core, but AI is the next frontier. Google’s real strength? Its grip on the digital ad world.

Exxon Mobil

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Big Oil’s still alive. Exxon lands at No. 8, flush from high energy prices and global demand. With more than $325 billion in revenue, it’s proof that fossil fuels remain powerful — even as the energy transition looms.

McKesson

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Healthcare logistics don’t get the spotlight, but McKesson’s supply chain powers hospitals and pharmacies across the U.S. Sitting at No. 9, it’s a behind-the-scenes giant with nearly $300 billion in sales.

Cencora (formerly AmerisourceBergen)

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Cencora rounds out the top 10. This pharmaceutical distributor plays a critical — if quiet — role in getting meds where they need to go. With rising demand for prescription drugs, business is booming.

Takeaways

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Retail dominates the top two, but healthcare is the real heavyweight with four companies in the top 10. Tech still prints money, and energy hasn’t gone quietly. Together, these firms shape how America spends, heals, shops, and powers its future — and they’re only getting bigger.

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