Betting on RFK’s Cabinet Nomination: How Will Senators Vote?

Once a Democrat, now an Independent, Robert F. Kennedy Jr. seeks Senate confirmation as Trump’s pick to lead the Department of Health and Human Services.

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After fears of his nomination being torpedoed, Robert F. Kennedy Jr. appears likely to be confirmed by the Senate.  

 

Kennedy was an environmental lawyer and a vaccine conspiracist. He believes vaccines cause autism, claims which have been debunked since the 1998 study alleging a connection was withdrawn. Kennedy ran as a Democrat in the presidential primary until Oct. 9, 2023 when he started running as an Independent. On Aug. 23, 2024, he suspended his presidential campaign and endorsed Trump. 


Trump nominated Kennedy to be the Secretary of Health and Human Services. The HHS Secretary oversees the CDC, Medicaid and Medicare programs, and coordinates federal and state responses to health emergencies. Polymarket gives Kennedy a 72% chance of being confirmed by the Senate.  

Kalshi’s market on specific senators only shows a few hesitant Republicans. Despite his pro-choice views, Kennedy matches the populist mood that helped bring Trump back to power. 

 

A few influential senators will still decide Kennedy’s fate: Susan Collins, Lisa Murkowski, Mitch McConnell, and John Curtis. Bill Cassidy is a likely yes vote, but like McConnell, he’ll be among the most influential behind the scenes.

Susan Collins

  • YES – 25%
  • NO –  84%

I anticipate having ample opportunity to question him and learn more about his views.

Senator Meeting: Collins has not released a statement about a meeting with Kennedy. 

 

Vote History: In the first two years of Trump’s first term, Collins voted in line with his positions 77% of the time. She only voted in line with his views 44% in the last two years of his first term. As a Republican senator from a blue state, Collins needs room to vote against some Republican positions.  


Expert Pick: The best bet on Collins is “no” on RFK Jr. She sits on the health panel that will hear his initial confirmation hearings, and voting against his anti-vax positions could be useful in her 2026 Senate campaign.  

Lisa Murkowski

  • YES – 27%
  • NO – 78%

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As she has done throughout her time in the Senate, she will determine on a case-by-case basis whether they are the right fit to successfully serve Alaska and our nation.

Senate Meeting: Murkowski met with Kennedy on Dec 19. She did not release a statement about the meeting. 

 

Vote History: Murkowski voted with Trump about 73% of the time. Like Collins, she voted in line with Trump more in the first half of his first term than his second. Murkowski voted in line with Trump about 82% of the time in Trump’s first two years and about 58% of the time in his next two. 


Expert Pick: The best bet is to vote “no” on Murkowski. Like Collins, she’s willing to vote against Trump and has political reasons to push back against some Republican policy choices.

Mitch McConnell

  • YES – 62% 
  • NO – 43%

 

Efforts to undermine public confidence in proven cures are not just uninformed — they’re dangerous. Anyone seeking the Senate’s consent to serve in the incoming Administration would do well to steer clear of even the appearance of association with such efforts. Sen. McConnell in response to Kennedy’s resurfaced petition to revoke FDA approval of the polio vaccine. (Dec. 15, 2024)

 

Senate Meeting: McConnell has not released a statement regarding a meeting with Kennedy. 

 

Vote History: McConnell voted in line with Trump’s wishes 91% of the time in Trump’s first term. During the first two years, McConnell voted in line with Trump 95% of the time. McConnell voted in line with Trump only 88% of the time in Trump’s third and fourth years. 


Expert Pick: The best bet is to vote “yes” on McConnell.

John Curtis

  • YES – 63%
  • NO – 45%

 

The Senate’s constitutional duty is to advise and give consent to the President and I intend to take that duty seriously, raise points that either strengthen the case for the candidate or raise questions for confirmation hearings, and ensure that Utahns’ voices are heard throughout this process. Sen. Curtis (Dec. 17, 2024)

 

Senate Meeting: Curtis has not released a statement about a meeting with Kennedy. 

 

Vote History: When he was in the House of Representatives, Curtis voted in line with Trump 91% of the time. Curtis went from voting with Trump 96% of the time in Trump’s first two years to 91% in the next two. 


Expert Pick: The best bet is to bet “yes” on Curtis.

Bill Cassidy

  • YES – 75%
  • NO – 27%

 

So I know that sounds novel around here, but I would like to talk to him…it ‘seems like a lot of stories are being written, and I have to make sure that I form my opinion on my own. Bill Cassidy quote to The Independent.

 

Senate Meeting: Cassidy will meet with Kennedy after Kennedy’s meeting with the Republican Health Education Labor and Pensions committee staff.

 

Vote History: Cassidy voted in line with Trump about 89% of the time over Trump’s first term. There was a large difference between the two halves of Trump’s first term. In Trump’s first two years, Cassidy voted in line with Trump 94% of the time. During the next two years, Cassidy voted in line with Trump 83% of the time. 


Expert Pick: The best bet is a “yes” from Cassidy after the Senate process has run its course.

Betting on RFK Jr.

If Kennedy makes it to a full Senate vote, the key senators as they stand now will likely vote this way: 

 

  • Susan Collins – No 
  • Lisa Murkowski – No 
  • Mitch McConnell – Yes
  • John Curtis – Yes
  • Bill Cassidy – Yes

Kennedy spent most of his career as an activist and a lawyer. He supported environmental causes, but he also spent decades profiting from promoting conspiracies about vaccine safety and vaccines’ connection to autism. 

 

Kennedy has also promoted abortion policies that are out of step with pro-life Republicans. During his presidential campaign, Kennedy endorsed abortion restrictions before the first trimester, then no restrictions, then abortion restrictions after fetal viability. He also proposed reducing the number of abortions by using Ukraine aid money to subsidize daycare. 

 

His popularity came from his messaging about hidden government forces infringing on individual liberties. Kennedy accused the Biden administration of censoring social media sites through “an entire censorship industrial complex.” In his hostility toward elites, Kennedy found common cause with Trump supporters and, eventually, Trump himself. 

 

As Trump’s controversial Cabinet nominees continue courting senators, Kennedy’s nomination seems increasingly likely–especially as the remaining Republican moderates eye 2026 re-election campaigns.

SENATOR STATE PARTY LIKELY VOTE
Ruben Gallego Arizona Democrat No
Mark Kelly Arizona Democrat No
Adam Schiff California Democrat No
Alex Padilla California Democrat No
John Hickenlooper Colorado Democrat No
Michael Bennet Colorado Democrat No
Chris Murphy Connecticut Democrat No
Richard Blumenthal Connecticut Democrat No
Lisa Blunt Rochester Delaware Democrat No
Chris Coons Delaware Democrat No
Jon Ossoff Georgia Democrat No
Raphael Warnock Georgia Democrat No
Mazie Hirono Hawaii Democrat No
Brian Schatz Hawaii Democrat No
Dick Durbin Illinois Democrat No
Tammy Duckworth Illinois Democrat No
Angela Alsobrooks Maryland Democrat No
Chris Van Hollen Maryland Democrat No
Elizabeth Warren Massachusetts Democrat No
Ed Markey Massachusetts Democrat No
Debbie Stabenow Michigan Democrat No
Gary Peters Michigan Democrat No
Amy Klobuchar Minnesota Democrat No
Tina Smith Minnesota Democrat No
Jacky Rosen Nevada Democrat No
Catherine Cortez Masto Nevada Democrat No
Jeanne Shaheen New Hampshire Democrat No
Maggie Hassan New Hampshire Democrat No
Bob Menendez New Jersey Democrat No
Cory Booker New Jersey Democrat No
Martin Heinrich New Mexico Democrat No
Ben Ray Luján New Mexico Democrat No
Kirsten Gillibrand New York Democrat No
Chuck Schumer New York Democrat No
Jeff Merkley Oregon Democrat No
Ron Wyden Oregon Democrat No
John Fetterman Pennsylvania Democrat No
Sheldon Whitehouse Rhode Island Democrat No
Jack Reed Rhode Island Democrat No
Peter Welch Vermont Democrat No
Tim Kaine Virginia Democrat No
Mark Warner Virginia Democrat No
Maria Cantwell Washington Democrat No
Patty Murray Washington Democrat No
Tammy Baldwin Wisconsin Democrat No
Angus King Maine Independent* No
Bernie Sanders Vermont Independent* No
Tommy Tuberville Alabama Republican Yes
Katie Britt Alabama Republican Yes
Dan Sullivan Alaska Republican Yes
Lisa Murkowski Alaska Republican Toss-Up
Tom Cotton Arkansas Republican Yes
John Boozman Arkansas Republican Yes
Rick Scott Florida Republican Yes
Marco Rubio Florida Republican Yes
Jim Risch Idaho Republican Yes
Mike Crapo Idaho Republican Yes
Jim Banks Indiana Republican Yes
Todd Young Indiana Republican Yes
Joni Ernst Iowa Republican Yes
Chuck Grassley Iowa Republican Yes
Roger Marshall Kansas Republican Yes
Jerry Moran Kansas Republican Yes
Mitch McConnell Kentucky Republican Toss-Up
Rand Paul Kentucky Republican Yes
Bill Cassidy Louisiana Republican Toss-Up
John Kennedy Louisiana Republican Yes
Susan Collins Maine Republican Toss-Up
Roger Wicker Mississippi Republican Yes
Cindy Hyde-Smith Mississippi Republican Yes
Josh Hawley Missouri Republican Yes
Eric Schmitt Missouri Republican Yes
Tim Sheehy Montana Republican Yes
Steve Daines Montana Republican Yes
Deb Fischer Nebraska Republican Yes
Pete Ricketts Nebraska Republican Yes
Thom Tillis North Carolina Republican Yes
Ted Budd North Carolina Republican Yes
Kevin Cramer North Dakota Republican Yes
John Hoeven North Dakota Republican Yes
Bernie Moreno Ohio Republican Yes
J.D. Vance Ohio Republican Yes
Markwayne Mullin Oklahoma Republican Yes
James Lankford Oklahoma Republican Yes
Dave McCormick Pennsylvania Republican Yes
Lindsey Graham South Carolina Republican Yes
Tim Scott South Carolina Republican Yes
Mike Rounds South Dakota Republican Yes
John Thune South Dakota Republican Yes
Marsha Blackburn Tennessee Republican Yes
Bill Hagerty Tennessee Republican Yes
Ted Cruz Texas Republican Yes
John Cornyn Texas Republican Yes
John Curtis Utah Republican Toss-Up
Mike Lee Utah Republican Yes
Jim Justice West Virginia Republican Yes
Shelley Moore Capito West Virginia Republican Yes
Ron Johnson Wisconsin Republican Yes
John Barrasso Wyoming Republican Yes
Cynthia Lummis Wyoming Republican Yes

  

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